Kardashian first rose to fame in October 2007 when she along with her two sisters, mother, brother, half-sisters, and stepfather starred in the E! television series, Keeping Up with the Kardashians. The series has aired five season to date, with two spin-off series.
Her first acting role was in the television series Beyond the Break. She then starred in the 2008 disaster film spoof Disaster Movie as Lisa. Kardashian appeared in the How I Met Your Mother episode "Benefits". She also appeared on the Season 3 premiere of the series 90210 with her sisters Khloé and Kourtney; they all played themselves. Kardashian was a guest hostess of WrestleMania XXIV and appeared as a guest judge during Cycle 13 of America's Next Top Model. On December 16, 2009, Kardashian made a guest star appearance on CBS's CSI: NY with Vanessa Minnillo.